Protein Details: Neuronal acetylcholine receptor subunit alpha-4
Protein ID
ICDB_Pro_0857
Protein Name
Neuronal acetylcholine receptor subunit alpha-4
Gene Name
CHRNA4
Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Length
627 amino acids
AlphaFoldDB
AF-Q19AE6-F1-model_v4.pdb
Function
After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Sequence
MELGGPGAPPPPLLPPLLLLLGAGFLPASSPVETRAHAEERLLKTLFSGYNKWSRPVANISDVVLVHFGLSIAQLIDVDEKNQMMTTNVWVKQEWYDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAITHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVSMQSHVDQLGLWESGEWVIVDAAGTYNTRKYECCAEVYPDITYAFVIRRLPLFYTINLIVPCLLISCLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMVFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDVVPRLLLMKRPSVVKDNCRRLIESMHKVASAPGFWPEPEGEPGVVSGERSRGPSRSASFRGPRDEPAEPQPACASPSDRVPAPQPSEGDPGSPCPLPDSCRPPPSTRAPGLTEARSLSFQHVSSAAERVEGGVRCRSWSIQGCAPQDEAASVAGGPVTSSPAFPKASAAELLPPDQPSPCRCRCRKEPSPNAVRKACGTRVPARHLPLSPALARAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWVFVIVCLLGTAGLFLPPWLAGMI
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
10.1124/mol.51.2.320
RefSeq
NP_990695.1